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Inhibition of CDKS by roscovitine suppressed LPS-induced (·)NO production through inhibiting NFκB activation and BH(4) biosynthesis in macrophages
In inflammatory diseases, tissue damage is critically associated with nitric oxide ((·)NO) and cytokines, which are overproduced in response to cellular release of endotoxins. Here we investigated the inhibitory effect of roscovitine, a selective inhibitor of cyclin-dependent kinases (CDKs) on (·)NO...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Physiological Society
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740392/ https://ncbi.nlm.nih.gov/pubmed/19553566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00138.2009 |
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