Glymphatic clearance controls state-dependent changes in brain lactate concentration

Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we show that the glymphatic system is responsible for state-dependent changes in brain lactate...

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Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Lundgaard, Iben, Lu, Minh Lon, Yang, Ezra, Peng, Weiguo, Mestre, Humberto, Hitomi, Emi, Deane, Rashid, Nedergaard, Maiken
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464705/
https://ncbi.nlm.nih.gov/pubmed/27481936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16661202
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