Glymphatic clearance controls state-dependent changes in brain lactate concentration

Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we show that the glymphatic system is responsible for state-dependent changes in brain lactate...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Lundgaard, Iben, Lu, Minh Lon, Yang, Ezra, Peng, Weiguo, Mestre, Humberto, Hitomi, Emi, Deane, Rashid, Nedergaard, Maiken
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464705/
https://ncbi.nlm.nih.gov/pubmed/27481936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16661202
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