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Glymphatic clearance controls state-dependent changes in brain lactate concentration

Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we show that the glymphatic system is responsible for state-dependent changes in brain lactate...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Lundgaard, Iben, Lu, Minh Lon, Yang, Ezra, Peng, Weiguo, Mestre, Humberto, Hitomi, Emi, Deane, Rashid, Nedergaard, Maiken
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464705/
https://ncbi.nlm.nih.gov/pubmed/27481936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16661202
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