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Glymphatic clearance controls state-dependent changes in brain lactate concentration

Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we show that the glymphatic system is responsible for state-dependent changes in brain lactate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Cereb Blood Flow Metab
Hauptverfasser: Lundgaard, Iben, Lu, Minh Lon, Yang, Ezra, Peng, Weiguo, Mestre, Humberto, Hitomi, Emi, Deane, Rashid, Nedergaard, Maiken
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464705/
https://ncbi.nlm.nih.gov/pubmed/27481936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16661202
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