NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

Hepatitis C virus (HCV) RNA is synthesized by the replicase complex (RC), a macromolecular assembly composed of viral non-structural proteins and cellular co-factors. Inhibitors of the HCV NS5A protein block formation of new RCs but do not affect RNA synthesis by pre-formed RCs. Without new RC forma...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Benzine, Tiffany, Brandt, Ryan, Lovell, William C., Yamane, Daisuke, Neddermann, Petra, De Francesco, Raffaele, Lemon, Stanley M., Perelson, Alan S., Ke, Ruian, McGivern, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464671/
https://ncbi.nlm.nih.gov/pubmed/28594932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006343
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