Impaired Replication of Hepatitis C Virus Containing Mutations in a Conserved NS5B Retinoblastoma Protein-Binding Motif

Hepatitis C virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central cell cycle regulator which is also targeted by oncoproteins expressed by DNA tumor viruses. HCV genome replication is also enhanced in proliferating cells. Thus, it is possible that HCV interactions wit...

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Detalhes bibliográficos
Main Authors: McGivern, David R., Villanueva, Rodrigo A., Chinnaswamy, Sreedhar, Kao, C. Cheng, Lemon, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708619/
https://ncbi.nlm.nih.gov/pubmed/19458004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00262-09
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