Impaired Replication of Hepatitis C Virus Containing Mutations in a Conserved NS5B Retinoblastoma Protein-Binding Motif

Hepatitis C virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central cell cycle regulator which is also targeted by oncoproteins expressed by DNA tumor viruses. HCV genome replication is also enhanced in proliferating cells. Thus, it is possible that HCV interactions wit...

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Autores principales: McGivern, David R., Villanueva, Rodrigo A., Chinnaswamy, Sreedhar, Kao, C. Cheng, Lemon, Stanley M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708619/
https://ncbi.nlm.nih.gov/pubmed/19458004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00262-09
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