Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus

Direct-acting antivirals (DAAs) targeting NS5A are broadly effective against hepatitis C virus (HCV) infections, but sustained virological response rates are generally lower in patients infected with genotype (gt)-1a than gt-1b viruses. The explanation for this remains uncertain. Here, we adopted a...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: Zhou, Shuntai, Williford, Sara E., McGivern, David R., Burch, Christina L., Hu, Fengyu, Benzine, Tiffany, Ingravallo, Paul, Asante-Appiah, Ernest, Howe, Anita Y.M., Swanstrom, Ronald, Lemon, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146077/
https://ncbi.nlm.nih.gov/pubmed/30081054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2018.07.024
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