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Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization
Protein−ligand interactions are frequently screened using nuclear magnetic resonance (NMR) spectroscopy. The dissociation constant (K(D)) of a ligand of interest can be determined via a spin-spin relaxation measurement of a reporter ligand, in a single scan when using hyperpolarization by means of d...
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| Publicat a: | Anal Chem |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5464406/ https://ncbi.nlm.nih.gov/pubmed/27723298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b03382 |
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