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Determination of binding affinities using hyperpolarized NMR with simultaneous 4-channel detection
Dissolution dynamic nuclear polarization (D-DNP) is a powerful technique to improve NMR sensitivity by a factor of thousands. Combining D-DNP with NMR-based screening enables to mitigate solubility or availability problems of ligands and target proteins in drug discovery as it can lower the concentr...
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| Veröffentlicht in: | J Magn Reson |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6201311/ https://ncbi.nlm.nih.gov/pubmed/30144688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmr.2018.08.002 |
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