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Affinity Screening Using Competition with Fluorine-19 Hyperpolarized Ligands**
Fluorine-19 NMR and hyperpolarization form a powerful combination for drug screening. Under a competitive equilibrium with a selected fluorinated reporter ligand, the dissociation constant (K(D)) of other ligands of interest is measurable using a single-scan Carr-Purcell-Meiboom-Gill (CPMG) experime...
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| Izdano u: | Angew Chem Int Ed Engl |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4472436/ https://ncbi.nlm.nih.gov/pubmed/25703090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411424 |
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