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The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
B lymphocyte differentiation is coordinated with the induction of high-level Ig secretion and expansion of the secretory pathway. Upon accumulation of unfolded proteins in the lumen of the ER, cells activate an intracellular signaling pathway termed the unfolded protein response (UPR). Two major pro...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546421/ https://ncbi.nlm.nih.gov/pubmed/15690081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200521848 |
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