OS06.7 PI-3Kγ inhibition suppresses glioblastoma tumorigenicity through disruption of an IL11-STAT3-MYC signaling axis between microglia and glioblastoma

While mutations in isocitrate dehydrogenase (IDH) gene are associated with favorable prognosis in glioblastoma patients, the biologic basis for favorable survival in patients with wild-type IDH (wtIDH) glioblastoma remains poorly understood. We identified that an inflammatory gene signature whose ex...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Li, J., Kaneda, M., Patel, K., Wang, J., Akers, J., Ramakrishnan, V., Jiang, T., Carter, B., Varner, J., Chen, C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
ORAL PRESENTATIONS
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463676/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.041
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