Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression

The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It remains unclear whether tumorigenicity exists as a static property of a few cells or as a dynamically acquired property. We used tumor-sphere a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kozono, David, Li, Jie, Nitta, Masayuki, Sampetrean, Oltea, Gonda, David, Kushwaha, Deepa S., Merzon, Dmitry, Ramakrishnan, Valya, Zhu, Shan, Zhu, Kaya, Matsui, Hiroko, Harismendy, Olivier, Hua, Wei, Mao, Ying, Kwon, Chang-Hyuk, Saya, Hideyuki, Nakano, Ichiro, Pizzo, Donald P., VandenBerg, Scott R., Chen, Clark C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522819/
https://ncbi.nlm.nih.gov/pubmed/26159421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501967112
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