PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Precision medicine in oncology leverages clinical observations of exceptional response. Toward an understanding of the molecular features that define this response, we applied an integrated, multiplatform analysis of RNA profiles derived from clinically annotated glioblastoma samples. This analysis...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Jie, Kaneda, Megan M., Ma, Jun, Li, Ming, Shepard, Ryan M., Patel, Kunal, Koga, Tomoyuki, Sarver, Aaron, Furnari, Frank, Xu, Beibei, Dhawan, Sanjay, Ning, Jianfang, Zhu, Hua, Wu, Anhua, You, Gan, Jiang, Tao, Venteicher, Andrew S., Rich, Jeremy N., Glass, Christopher K., Varner, Judith A., Chen, Clark C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072253/
https://ncbi.nlm.nih.gov/pubmed/33846242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009290118
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