PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Precision medicine in oncology leverages clinical observations of exceptional response. Toward an understanding of the molecular features that define this response, we applied an integrated, multiplatform analysis of RNA profiles derived from clinically annotated glioblastoma samples. This analysis...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Li, Jie, Kaneda, Megan M., Ma, Jun, Li, Ming, Shepard, Ryan M., Patel, Kunal, Koga, Tomoyuki, Sarver, Aaron, Furnari, Frank, Xu, Beibei, Dhawan, Sanjay, Ning, Jianfang, Zhu, Hua, Wu, Anhua, You, Gan, Jiang, Tao, Venteicher, Andrew S., Rich, Jeremy N., Glass, Christopher K., Varner, Judith A., Chen, Clark C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072253/
https://ncbi.nlm.nih.gov/pubmed/33846242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009290118
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