Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyl transferase of Polycomb repressive complex 2, mediates transcriptional repression of pro-differentiation genes in both normal and neo...

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Main Authors: Kim, Eunhee, Kim, Misuk, Woo, Dong-Hun, Shin, Yongjae, Shin, Jihye, Chang, Nakho, Oh, Young Taek, Kim, Hong, Rheey, Jingeun, Nakano, Ichiro, Lee, Cheolju, Joo, Kyeung Min, Rich, Jeremy N., Nam, Do-Hyun, Lee, Jeongwu
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109796/
https://ncbi.nlm.nih.gov/pubmed/23684459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.04.008
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