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STAT3-driven transcription depends upon the dimethylation of K49 by EZH2
Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same enzymes that also modify histones, with important functional consequences. We have identified a previously unrecognized dimethylation of K49 of STAT3 that is crucial for the expression of many IL-6–dependent gen...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4386339/ https://ncbi.nlm.nih.gov/pubmed/25767098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503152112 |
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