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EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells

Activation of nuclear factor κB (NFκB) is a central event in the responses of normal cells to inflammatory signals, and the abnormal constitutive activation of NFκB is important for the survival of most cancer cells. In nonmalignant human cells, EGF stimulates robust activation of NFκB. The kinase a...

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Bibliografiske detaljer
Main Authors: De, Sarmishtha, Dermawan, Josephine Kam Tai, Stark, George R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136585/
https://ncbi.nlm.nih.gov/pubmed/25071181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412390111
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