Non-Receptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs are poorly defined. Here we demonstrate that the non-receptor tyrosine kinase BMX...

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Main Authors: Guryanova, Olga A., Wu, Qiulian, Cheng, Lin, Lathia, Justin D., Huang, Zhi, Yang, Jinbo, MacSwords, Jennifer, Eyler, Christine E., McLendon, Roger E., Heddleston, John M., Shou, Weinian, Hambardzumyan, Dolores, Lee, Jeongwu, Hjelmeland, Anita B., Sloan, Andrew E., Bredel, Markus, Stark, George R., Rich, Jeremy N., Bao, Shideng
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076106/
https://ncbi.nlm.nih.gov/pubmed/21481791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.03.004
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