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Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

Cullin RING E3 ubiquitin ligases (CRLs) function in the ubiquitin proteasome system to catalyze the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins. CRLs are large dynamic complexes and attractive drug targets for the development of small-molecule inhibitors and chem...

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Bibliografiske detaljer
Udgivet i:Structure
Main Authors: Cardote, Teresa A.F., Gadd, Morgan S., Ciulli, Alessio
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462531/
https://ncbi.nlm.nih.gov/pubmed/28591624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.04.009
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