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Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex
Cullin RING E3 ubiquitin ligases (CRLs) function in the ubiquitin proteasome system to catalyze the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins. CRLs are large dynamic complexes and attractive drug targets for the development of small-molecule inhibitors and chem...
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| Published in: | Structure |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cell Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5462531/ https://ncbi.nlm.nih.gov/pubmed/28591624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.04.009 |
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