VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been implicated as a SOCS-box protein, but lacks a C-ter...

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Autores principales: Kamura, Takumi, Maenaka, Katsumi, Kotoshiba, Shuhei, Matsumoto, Masaki, Kohda, Daisuke, Conaway, Ronald C., Conaway, Joan Weliky, Nakayama, Keiichi I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC535916/
https://ncbi.nlm.nih.gov/pubmed/15601820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1252404
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