The accumulation of MMS-induced single strand breaks in G(1) phase is recombinogenic in DNA polymerase β defective mammalian cells

DNA polymerase (Pol) β null mouse embryonic fibroblasts provide a useful cell system to investigate the effects of alterations in base excision repair (BER) on genome stability. These cells are characterized by hypersensitivity to the cytotoxic effects of methyl methanesulfonate (MMS) and by decreas...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Pascucci, Barbara, Russo, Maria Teresa, Crescenzi, Marco, Bignami, Margherita, Dogliotti, Eugenia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2005
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC546155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15647510/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gki168
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