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The accumulation of MMS-induced single strand breaks in G(1) phase is recombinogenic in DNA polymerase β defective mammalian cells

DNA polymerase (Pol) β null mouse embryonic fibroblasts provide a useful cell system to investigate the effects of alterations in base excision repair (BER) on genome stability. These cells are characterized by hypersensitivity to the cytotoxic effects of methyl methanesulfonate (MMS) and by decreas...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pascucci, Barbara, Russo, Maria Teresa, Crescenzi, Marco, Bignami, Margherita, Dogliotti, Eugenia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2005
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC546155/
https://ncbi.nlm.nih.gov/pubmed/15647510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki168
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