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A mutant endonuclease IV of Escherichia coli loses the ability to repair lethal DNA damage induced by hydrogen peroxide but not that induced by methyl methanesulfonate.

A mutant allele of the Escherichia coli nfo gene encoding endonuclease IV, nfo-186, was cloned into plasmid pUC18. When introduced into an E. coli xthA nfo mutant, the gene product of nfo-186 complemented the hypersensitivity of the mutant to methyl methanesulfonate (MMS) but not to hydrogen peroxid...

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Detalhes bibliográficos
Publicado no:J Bacteriol
Principais autores: Izumi, T, Ishizaki, K, Ikenaga, M, Yonei, S
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207485/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1280256/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.174.23.7711-7716.1992
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