Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells

UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) plays a crucial role in DNA methylation, chromatin remodeling and gene expression and is aberrantly upregulated in various types of human cancers. However, the precise role of UHRF1 in cancer remains controversial. In this study, we observed...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kim, Ji-Hyun, Shim, Jae-Woong, Eum, Da-Young, Kim, Sung Dae, Choi, Si Ho, Yang, Kwangmo, Heo, Kyu, Park, Moon-Taek
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459852/
https://ncbi.nlm.nih.gov/pubmed/28584306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02935-2
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