Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells

UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) plays a crucial role in DNA methylation, chromatin remodeling and gene expression and is aberrantly upregulated in various types of human cancers. However, the precise role of UHRF1 in cancer remains controversial. In this study, we observed...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kim, Ji-Hyun, Shim, Jae-Woong, Eum, Da-Young, Kim, Sung Dae, Choi, Si Ho, Yang, Kwangmo, Heo, Kyu, Park, Moon-Taek
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459852/
https://ncbi.nlm.nih.gov/pubmed/28584306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02935-2
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