CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of p53 and Pten somatic mutation in HCC development, we established CRISPR/Cas9-mediated somatic gene disruption...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Yongzhen, Qi, Xuewei, Zeng, Zhenzhen, Wang, Lu, Wang, Jie, Zhang, Ting, Xu, Qiang, Shen, Congle, Zhou, Guangde, Yang, Shaomin, Chen, Xiangmei, Lu, Fengmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459841/
https://ncbi.nlm.nih.gov/pubmed/28584302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03070-8
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