Activation of Soluble Guanylyl Cyclase at the Leading Edge during Dictyostelium Chemotaxis

Dictyostelium contains two guanylyl cyclases, GCA, a 12-transmembrane enzyme, and sGC, a homologue of mammalian soluble adenylyl cyclase. sGC provides nearly all chemoattractant-stimulated cGMP formation and is essential for efficient chemotaxis toward cAMP. We show that in resting cells the major f...

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Pubblicato in:Mol Biol Cell
Autori principali: Veltman, Douwe M., Roelofs, Jeroen, Engel, Ruchira, Visser, Antonie J.W.G., Van Haastert, Peter J.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Cell Biology 2005
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Articles
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545927/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15601898/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E04-08-0701
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