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Activation of Soluble Guanylyl Cyclase at the Leading Edge during Dictyostelium Chemotaxis
Dictyostelium contains two guanylyl cyclases, GCA, a 12-transmembrane enzyme, and sGC, a homologue of mammalian soluble adenylyl cyclase. sGC provides nearly all chemoattractant-stimulated cGMP formation and is essential for efficient chemotaxis toward cAMP. We show that in resting cells the major f...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Cell Biology
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545927/ https://ncbi.nlm.nih.gov/pubmed/15601898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-08-0701 |
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