Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia

The autologous ALDH bright (ALDH(br)) cell therapy for ischemic injury is clinically safe and effective, while the underlying mechanism remains elusive. Here, we demonstrated that the glycolysis dominant metabolism of ALDH(br) cells is permissive to restore blood flow in an ischemic hind limb model...

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Bibliografiske detaljer
Udgivet i:Redox Biol
Main Authors: Sun, Xiaolei, Zhu, Hong, Dong, Zhen, Liu, Xiangwei, Ma, Xin, Han, Shasha, Lu, Fei, Wang, Peng, Qian, Sanli, Wang, Cong, Shen, Cheng, Zhao, Xiaona, Zou, Yunzeng, Ge, Junbo, Sun, Aijun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458766/
https://ncbi.nlm.nih.gov/pubmed/28582728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.018
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