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Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase
The genetic code is fixed in aminoacylation reactions catalyzed by aminoacyl-tRNA synthetases. Amino acid discrimination occurs at two sites: one for amino acid activation and aminoacylation and one for editing misactivated amino acids. Although the active site sieves out bulkier amino acids, misact...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545860/ https://ncbi.nlm.nih.gov/pubmed/15657145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409024102 |
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