Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase

Class I aminoacyl-tRNA synthetases catalyze editing reactions that prevent ambiguity from entering the genetic code. Misactivated amino acids are translocated in cis from the active site for aminoacylation to the center for editing, located ≈30 Å away. Mutational analysis has functionally separated...

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Bibliographic Details
Main Authors: Bishop, Anthony C., Beebe, Kirk, Schimmel, Paul R.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC141022/
https://ncbi.nlm.nih.gov/pubmed/12515858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237335100
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