Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase
Class I aminoacyl-tRNA synthetases catalyze editing reactions that prevent ambiguity from entering the genetic code. Misactivated amino acids are translocated in cis from the active site for aminoacylation to the center for editing, located ≈30 Å away. Mutational analysis has functionally separated...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2003
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12515858/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0237335100 |
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