Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo

In an effort to expand the scope of protein mutagenesis, we have completed the first steps toward a general method to allow the site-specific incorporation of unnatural amino acids into proteins in vivo. Our approach involves the generation of an “orthogonal” suppressor tRNA that is uniquely acylate...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Liu, David R., Magliery, Thomas J., Pastrnak, Miro, Schultz, Peter G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23315/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9294168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.19.10092
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