Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, selective and reversible chemical probes that simultaneously inhibit the G9a and DNMTs methyltr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: San José-Enériz, Edurne, Agirre, Xabier, Rabal, Obdulia, Vilas-Zornoza, Amaia, Sanchez-Arias, Juan A., Miranda, Estibaliz, Ugarte, Ana, Roa, Sergio, Paiva, Bruno, Estella-Hermoso de Mendoza, Ander, Alvarez, Rosa María, Casares, Noelia, Segura, Victor, Martín-Subero, José I., Ogi, François-Xavier, Soule, Pierre, Santiveri, Clara M., Campos-Olivas, Ramón, Castellano, Giancarlo, de Barrena, Maite Garcia Fernandez, Rodriguez-Madoz, Juan Roberto, García-Barchino, Maria José, Lasarte, Juan Jose, Avila, Matias A, Martinez-Climent, Jose Angel, Oyarzabal, Julen, Prosper, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458547/
https://ncbi.nlm.nih.gov/pubmed/28548080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15424
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