Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor

Although T regulatory cells (Treg) are essential for the prevention of autoimmune diseases, their immunoregulatory function restrains the induction of immune responses against cancer. Thus, development of inhibitors of FOXP3, a key transcription factor for the immunosuppressive activity of Treg, mig...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lozano, Teresa, Gorraiz, Marta, Lasarte-Cía, Aritz, Ruiz, Marta, Rabal, Obdulia, Oyarzabal, Julen, Hervás-Stubbs, Sandra, Llopiz, Diana, Sarobe, Pablo, Prieto, Jesús, Casares, Noelia, Lasarte, Juan José
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641083/
https://ncbi.nlm.nih.gov/pubmed/29069740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17845
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