Genetic Modification of CD8(+) T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Adoptive immunotherapy with ex vivo-expanded tumor-infiltrating lymphocytes (TILs) has achieved objective clinical responses in a significant number of patients with cancer. The failure of many patients to develop long-term tumor control may be, in part, due to exhaustion of transferred T cells in t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lozano, Teresa, Chocarro, Silvia, Martin, Celia, Lasarte-Cia, Aritz, del Valle, Cynthia, Gorraiz, Marta, Sarrión, Patricia, Ruiz de Galarreta, Marina, Lujambio, Amaia, Hervás-Stubbs, Sandra, Sarobe, Pablo, Casares, Noelia, Lasarte, Juan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934060/
https://ncbi.nlm.nih.gov/pubmed/31921216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02990
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