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High-resolution cryo-EM proteasome structures in drug development

With the recent advances in biological structural electron microscopy (EM), protein structures can now be obtained by cryo-EM and single-particle analysis at resolutions that used to be achievable only by crystallographic or NMR methods. We have explored their application to study protein–ligand int...

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Detalles Bibliográficos
Publicado en:Acta Crystallogr D Struct Biol
Main Authors: Morris, Edward P., da Fonseca, Paula C. A.
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458494/
https://ncbi.nlm.nih.gov/pubmed/28580914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798317007021
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