High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx

The 26S proteasome is an ATP-dependent dynamic 2.5 MDa protease that regulates numerous essential cellular functions through degradation of ubiquitinated substrates. Here we present a near-atomic-resolution cryo-EM map of the S. cerevisiae 26S proteasome in complex with ADP-AlFx. Our biochemical and...

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Bibliografiske detaljer
Udgivet i:Cell Res
Main Authors: Ding, Zhanyu, Fu, Zhenglin, Xu, Cong, Wang, Yifan, Wang, Yanxing, Li, Junrui, Kong, Liangliang, Chen, Jinhuan, Li, Na, Zhang, Rongguang, Cong, Yao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339833/
https://ncbi.nlm.nih.gov/pubmed/28106073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.12
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