Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). However, due to the lack of a mammalian PA28αβ-iCP structure, how PA28αβ regulates proteasome remains elusive. Here we present the complete architectures of the mammal...

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Publicat a:Nat Commun
Autors principals: Chen, Jinhuan, Wang, Yifan, Xu, Cong, Chen, Kaijian, Zhao, Qiaoyu, Wang, Shutian, Yin, Yue, Peng, Chao, Ding, Zhanyu, Cong, Yao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854634/
https://ncbi.nlm.nih.gov/pubmed/33531497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21028-3
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