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Identification of small molecule inhibitors of the Aurora-A/TPX2 complex

Aurora kinases are a family of cell division regulators that govern the correct assembly of a bipolar mitotic spindle and the fidelity of chromosome segregation. Their overexpression is associated with genomic instability and aneuploidy, and is frequently observed in cancer. Accordingly, competitive...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Asteriti, Italia Anna, Daidone, Frederick, Colotti, Gianni, Rinaldo, Serena, Lavia, Patrizia, Guarguaglini, Giulia, Paiardini, Alessandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458272/
https://ncbi.nlm.nih.gov/pubmed/28389630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16738
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