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Control of Aurora-A stability through interaction with TPX2

The Aurora-A kinase has well-established roles in spindle assembly and function and is frequently overexpressed in tumours. Its abundance is cell cycle regulated, with a peak in G2 and M phases, followed by regulated proteolysis at the end of mitosis. The microtubule-binding protein TPX2 plays a maj...

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Main Authors: Giubettini, Maria, Asteriti, Italia A., Scrofani, Jacopo, De Luca, Maria, Lindon, Catherine, Lavia, Patrizia, Guarguaglini, Giulia
格式: Artigo
語言:Inglês
出版: Company of Biologists 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001410/
https://ncbi.nlm.nih.gov/pubmed/21147853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.075457
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