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Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces
BACKGROUND: Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through whi...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226445/ https://ncbi.nlm.nih.gov/pubmed/22011530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-131 |
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