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Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

BACKGROUND: Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through whi...

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Bibliografiska uppgifter
Huvudupphovsmän: Asteriti, Italia A, Giubettini, Maria, Lavia, Patrizia, Guarguaglini, Giulia
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226445/
https://ncbi.nlm.nih.gov/pubmed/22011530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-131
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