Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

The scaffolding protein insulin receptor tyrosine kinase substrate p53 (IRSp53), a ubiquitous regulator of the actin cytoskeleton, mediates filopodia formation under the control of Rho-family GTPases. IRSp53 comprises a central SH3 domain, which binds to proline-rich regions of a wide range of actin...

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Bibliographic Details
Main Authors: Millard, Thomas H, Bompard, Guillaume, Heung, Man Yeung, Dafforn, Timothy R, Scott, David J, Machesky, Laura M, Fütterer, Klaus
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545821/
https://ncbi.nlm.nih.gov/pubmed/15635447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600535
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