mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation

Filopodia are dynamic actin-rich cell surface protrusions involved in cell migration, axon guidance, and wound healing. The RhoGTPase Cdc42 generates filopodia via IRSp53, a multidomain protein that links the processes of plasma membrane deformation and actin dynamics required for their formation in...

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Bibliographic Details
Main Authors: Goh, Wah Ing, Lim, Kim Buay, Sudhaharan, Thankiah, Sem, Kai Ping, Bu, Wenyu, Chou, Ai Mei, Ahmed, Sohail
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281667/
https://ncbi.nlm.nih.gov/pubmed/22179776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.305102
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