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Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
The scaffolding protein insulin receptor tyrosine kinase substrate p53 (IRSp53), a ubiquitous regulator of the actin cytoskeleton, mediates filopodia formation under the control of Rho-family GTPases. IRSp53 comprises a central SH3 domain, which binds to proline-rich regions of a wide range of actin...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545821/ https://ncbi.nlm.nih.gov/pubmed/15635447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600535 |
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