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A highly conserved redox-active Mx((2))CWx((6))R motif regulates Zap70 stability and activity
ζ-associated protein of 70 kDa (Zap70) is crucial for T-cell receptor (TCR) signaling. Loss of Zap70 in both humans and mice results in severe immunodeficiency. On the other hand, the expression of Zap70 in B-cell malignancies correlates with the severity of the disease. Because of its role in immun...
Gorde:
| Argitaratua izan da: | Oncotarget |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Impact Journals LLC
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458169/ https://ncbi.nlm.nih.gov/pubmed/28415650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16486 |
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