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A highly conserved redox-active Mx((2))CWx((6))R motif regulates Zap70 stability and activity
ζ-associated protein of 70 kDa (Zap70) is crucial for T-cell receptor (TCR) signaling. Loss of Zap70 in both humans and mice results in severe immunodeficiency. On the other hand, the expression of Zap70 in B-cell malignancies correlates with the severity of the disease. Because of its role in immun...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458169/ https://ncbi.nlm.nih.gov/pubmed/28415650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16486 |
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