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The Cytidine Deaminase APOBEC3 Family is Subject to Transcriptional Regulation by p53

The APOBEC3 (A3) family of proteins are DNA cytidine deaminases that act as sentinels in the innate immune response against retroviral infections and are responsive to interferon. Recently, a few A3 genes were identified as potent enzymatic sources of mutations in several human cancers. Using human...

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Publicado en:Mol Cancer Res
Main Authors: Menendez, Daniel, Nguyen, Thuy-Ai, Snipe, Joyce, Resnick, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457717/
https://ncbi.nlm.nih.gov/pubmed/28232385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0019
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